PROCEDIMIENTO DE TERAPIA PARA CANCERES QUE EXPRESAN EL ANTIGENO CD40.
摘要
Methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing cells, such as B cells.
申请公布号
ES2346977(T3)
申请公布日期
2010.10.22
申请号
ES20040810421T
申请日期
2004.11.04
申请人
NOVARTIS VACCINES AND DIAGNOSTICS, INC.;XOMA TECHNOLOGY LTD.
发明人
LONG, LI;LUQMAN, MOHAMMAD;YABANNAVAR, ASHA;ZAROR, ISABEL;HURST, DEBORAH;LOPES DE MENEZES, DANIEL, E.