| 发明名称 |
PROCESS FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR |
| 摘要 |
The invention provides a process for the preparation of a compound of Formula 1, comprising coupling a carboxylic acid of Formula 2 with an aniline of Formula 3 in the presence of a coupling agent. |
| 申请公布号 |
US2010267768(A1) |
申请公布日期 |
2010.10.21 |
| 申请号 |
US20100728173 |
申请日期 |
2010.03.19 |
| 申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
DEMATTEI JOHN;LOOKER ADAM R.;NEUBERT-LANGILLE BOBBIANNA;TRUDEAU MARTIN;ROEPER STEFANIE;RYAN MICHAEL P.;YAP DAHRIKA MILFRED LAO;KRUEGER BRIAN R.;GROOTENHUIS PETER D.J.;VAN GOOR FREDRICK F.;BOTFIELD MARTYN C.;ZLOKARNIK GREGOR |
| 分类号 |
A61K31/47;A61P1/16;A61P1/18;A61P3/00;A61P3/10;A61P7/12;A61P11/06;A61P15/10;A61P25/28;A61P37/00;A61P37/08;C07C69/96;C07D215/233;C07D307/77;C12N5/07;C12Q1/02 |
主分类号 |
A61K31/47 |
| 代理机构 |
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