| 发明名称 |
PROCESS FOR THE PREPARATION OF DONEPEZIL HYDROCHLORIDE |
| 摘要 |
<p>The present invention provides a process for preparing donepezil or a salt thereof, the process comprising reducing a 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2- yl)methylene]pyridonium halide of formula (II), wherein X is bromide or chloride, in the presence of an ionic compound, a solvent, a catalyst and a source of hydrogen, to form donepezil and optionally converting the donepezil to the salt thereof.</p> |
| 申请公布号 |
WO2009118516(A8) |
申请公布日期 |
2010.10.21 |
| 申请号 |
WO2009GB00776 |
申请日期 |
2009.03.24 |
| 申请人 |
CIPLA LIMITED;RAO, DHARMARAJ RAMACHANDRA;KANKAN, RAJENDRA NARAYANRAO;PATHI, SRINIVAS LAXMINARAYAN;CURTIS, PHILIP ANTHONY |
发明人 |
RAO, DHARMARAJ RAMACHANDRA;KANKAN, RAJENDRA NARAYANRAO;PATHI, SRINIVAS LAXMINARAYAN |
| 分类号 |
A61K31/445;A61P25/28;C07D213/20;C07D295/03 |
主分类号 |
A61K31/445 |
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