ENGINEERED PROTEINS WITH HIGH AFFINITY FOR DOTA CHELATES

摘要

Compositions and methods for the treatment of cancer and infectious disease The compositions include engineered proteins that specifically bind a target (e g, a cellular protein) on a cancerous cell or a pathogen and a metal chelate comprising DOT A, or an active variant thereof, and a metal ion such as a radionuclide are disclosed By virtue of the multiple binding sites, the engineered protein effectively delivers a metal chelate to a cell one wishes to destroy.