D,L-2-AMINOTHIAZOLINE-4-CARBOXYLIC ACID COMPOUNDS AS L-CYSTINE INTERMEDIATE OF AMINO TYPED AND A PREPARATION METHOD OF THE SAME

摘要

PURPOSE: A method for preparing D,L-2-aminothiazoline-4-carboxylic acid compound is provided to obtain target compounds at high purity and high yield. CONSTITUTION: A method for preparing D,L-2-aminothizoline-4-carboxylic acid compound of chemical formula 5 comprises: a step of performing chlorination addition of dichloropyropionitrile of chemical formula 3; a step of reacting the compound of chemical formula 3 with thiourea of chemical formula 4 to obtain a thiazine derivative of chemical formula 5; and a step of adding base to thiazine derivative of chemical formula 5 to obtain D,L-2-aminothiazoline-4carboxylic acid compound of chemical formula 1.