发明名称 |
SPANX-B POLYPEPTIDES AND THEIR USE |
摘要 |
It is disclosed herein that SPANX-B is uniquely expressed in a number of human tumors and that SPANX-B is an immunogenic antigen that is recognized by human T cells inducing helper CD4+ and cytolytic CD8+ T cell responses. Specific SPANX-B polypeptides and polynucleotides are disclosed that can be used to generate an immune response. In several embodiments, these polypeptides can be used for the treatment of a variety of cancers, including melanoma, colon carcinoma, ovarian cancer, breast cancer, myeloma, lung carcinoma and renal cancer. |
申请公布号 |
WO2010099472(A3) |
申请公布日期 |
2010.10.21 |
申请号 |
WO2010US25633 |
申请日期 |
2010.02.26 |
申请人 |
THE U.S.A. OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;BIRAGYN, ARYA;LARIONOV, VLADIMIR, L. |
发明人 |
BIRAGYN, ARYA;LARIONOV, VLADIMIR, L. |
分类号 |
A61K39/00;A61P35/00;C07K7/06;C07K7/08;C07K14/82;C12N15/12;C12N15/86 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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