发明名称 |
FLUORO SUBSTITUTED PYRIMIDINE COMPOUNDS AS JAK3 INHIBITORS |
摘要 |
<p>The present invention relates to compounds of formula (I) wherein AA, R2 to R7 and X1 to X3 have the meaning as cited in the description and the claims. Said compounds are useful as selective inhibitors of JAK3 over JAK2 for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.</p> |
申请公布号 |
WO2010118986(A1) |
申请公布日期 |
2010.10.21 |
申请号 |
WO2010EP54685 |
申请日期 |
2010.04.09 |
申请人 |
CELLZOME LIMITED;HARRISON, RICHARD JOHN;HOBSON, ANDREW;RAMSDEN, NIGEL |
发明人 |
HARRISON, RICHARD JOHN;HOBSON, ANDREW;RAMSDEN, NIGEL |
分类号 |
C07D403/12;A61K31/506;A61K31/5377;A61P35/00;C07D239/48;C07D407/12 |
主分类号 |
C07D403/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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