| 发明名称 |
METHOD FOR THE PREPARATION OF DULOXETINE HYDROCHLORIDE |
| 摘要 |
The present invention relates to an improved process for the preparation of Duloxetine and its intermediates (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine by reacting (S)-(+)-N,N-dimethyl-3-(2-thienyl)-3-hydroxypropanamine with 1-fluoronaphthalene in the presence of a base; wherein the improvement lies in conducting the reaction in the absence of solvent.
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| 申请公布号 |
US2010267968(A1) |
申请公布日期 |
2010.10.21 |
| 申请号 |
US20080734580 |
申请日期 |
2008.12.26 |
| 申请人 |
ORCHID CHEMICALS & PHARMACEUTICALS LIMITED |
发明人 |
SIRIPRAGADA MAHENDER RAO;THANGAVEL ARULMOLI;ARUNAGIRI MUTHULINGHAM;YARROJU PRASADACHARI;TAYYALA KIRANMYE |
| 分类号 |
C07D333/20 |
主分类号 |
C07D333/20 |
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