BIOLOGICAL MARKERS PREDICTIVE OF ANTI-CANCER RESPONSE TO EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITORS
摘要
<p>The present invention provides diagnostic methods for predicting the effectiveness of treatment of a cancer patient with an EGFR kinase inhibitor. These methods are based on the surprising discovery that the effectiveness of treatment with an EGFR kinase inhibitor is predicted by whether a patient's tumor cells express a high or a low level of the biomarkers vimentin and E-cadherin, such that patients whose tumors express a high level of at least one of the biomarkers vimentin and E-cadherin have a longer overall survival and progression free survival than patients whose tumors express a low level of both vimentin and E-cadherin. The present invention further provides a method for treating tumors or tumor metastases in a patient, comprising the steps of diagnosing a patient's likely responsiveness to an EGFR kinase inhibitor by assessing whether tumor cells express a high level of at least one of the biomarkers vimentin and E-cadherin, and administering to said patient a therapeutically effective amount of an EGFR kinase inhibitor (e.g. erlotinib), particularly when effectiveness of the inhibitor is predicted.</p>
申请公布号
WO2010120966(A1)
申请公布日期
2010.10.21
申请号
WO2010US31144
申请日期
2010.04.15
申请人
OSI PHARMACEUTICALS, INC.;RICHARDSON, FRANK, C.;YOUNG, G., DAVID;WOLF, JULIE, L.;SENNELLO, REGINA, M.
发明人
RICHARDSON, FRANK, C.;YOUNG, G., DAVID;WOLF, JULIE, L.;SENNELLO, REGINA, M.