发明名称 4-AZETIDINYL-1-HETEROATOM LINKED-CYCLOHEXANE ANTAGONISTS OF CCR2
摘要 The present invention comprises compounds of Formula (I). wherein: X, R1, R2, R3, and R4 are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
申请公布号 CA2758929(A1) 申请公布日期 2010.10.21
申请号 CA20102758929 申请日期 2010.04.15
申请人 JANSSEN PHARMACEUTICA NV 发明人 ZHANG, XUQING;HUFNAGEL, HEATHER RAE;SUI, ZHIHUA
分类号 C07D401/08;A61K31/433;A61K31/437;A61K31/4427;A61P3/10;A61P29/00;C07D403/08;C07D405/08;C07D413/08;C07D417/08 主分类号 C07D401/08
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