<p>The invention provides methods for isolating proteins in purified form from mixtures by precipitation with citrate. The methods are advantageous in that they effectively separate a protein from lower molecular weight contaminants, including fragments or portions of the protein. Such methods are particularly useful for purifying antibodies from mixtures containing antibody proteolytic fragments and unpaired chains.</p>
申请公布号
WO2010120739(A1)
申请公布日期
2010.10.21
申请号
WO2010US30841
申请日期
2010.04.13
申请人
BRISTOL-MYERS SQUIBB COMPANY;ARUNAKUMARI, ALAHARI;FERREIRA, GISELA MARIA MARQUES
发明人
ARUNAKUMARI, ALAHARI;FERREIRA, GISELA MARIA MARQUES