| 摘要 |
The present invention relates to a composition comprising an extract of Tiarella polyphylla, and tiarellic acid isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Tiarella polyphylla and the tiarellic acid isolated therefrom shows the inhibitory effect on the LTC<SUB>4</SUB> release in vitro test and the suppressive effect on the IgE level and the cytokine(IL-4, IL-5 and IL- 13) production, airway hyperresponsiveness, and leukocyte infiltration in OVA-induced asthmatic mice. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease. |
| 申请人 |
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY |
发明人 |
LEE, HYEONG KYU;OH, SEI RYANG;AHN, KYUNG SEOP;LEE, JOONG KU;LEE, SAN KU;KIM, JUNG HEE;KIM, DOO YOUNG;QUAN, GUI HUA;KWON, OK KYOUNG;KIM, EUN AH;CHOI, SOON JA;SHEN, GUANG HAI;KIM, MI JIN;PARK, BO YOUNG;MIN, BYUNG SUN;HAN, GYOON HEE;PARK, HEA YOUNG;KIM, GUN CHEOL;KIM, JOO HEON;KIM, SO YOUNG |
