| 摘要 |
FIELD: medicine. ^ SUBSTANCE: invention relates to field of biotechnology, virology and medicine. Described is immunogenic composition of preliminarily determined inactivated strains of human immunodeficiency virus (HIV). Inactivation is carried out by means of psoralen and ultrasonic radiation. Composition is made more efficient by removal of structural HIV peculiarities, which prevent immune response. In particular, sialic acid is removed in order to enhance immune recognition of composition and for weakening of complimentary H factor binding. Also for prevention of complimentary H factor binding CD55 and CD59 are removed. Determination of strains for inactivation can be realised by means of immunotherapeutic genotyping or probabilistic assessment of infection risk. ^ EFFECT: invention can be used in medicine. ^ 30 cl, 3 dwg |
