| 发明名称 |
Conjugates of hydroxyalkyl starch and an active agent |
| 摘要 |
The invention relates to compounds, comprising a conjugate of hydroxyalkyl starch (HAS) and an active agent, whereby the hydroxyalkyl starch is either directly covalently bonded to the active agent, or by means of a linker. The invention further relates to methods for the production of a covalent HAS-active agent conjugate, whereby HAS and an active agent are reacted in a reaction medium, characterised in that the reaction medium is water or a mixture of water and an organic solvent, comprising at least 10 wt. % water.
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| 申请公布号 |
US7816516(B2) |
申请公布日期 |
2010.10.19 |
| 申请号 |
US20040472002 |
申请日期 |
2004.09.22 |
| 申请人 |
FRESENIUS KABI DEUTSCHLAND GMBH |
发明人 |
SOMMERMEYER KLAUS;EICHNER WOLFRAM;FRIE SVEN;JUNGHEINRICH CORNELIUS;SCHARPF ROLAND;LUTTERBECK KATHARINA;HEMBERGER JURGEN;ORLANDO MICHELE |
| 分类号 |
C08B31/18;A61K31/718;A61K38/00;A61K45/00;A61K47/36;A61K47/48;A61K48/00;A61P3/02;A61P3/04;A61P3/10;A61P5/00;A61P5/44;A61P5/50;A61P7/00;A61P7/06;A61P9/06;A61P11/06;A61P13/00;A61P13/12;A61P23/00;A61P23/02;A61P25/24;A61P29/00;A61P31/00;A61P31/04;A61P31/06;A61P31/10;A61P31/12;A61P33/00;A61P35/00;A61P35/02;A61P35/04;A61P37/04;A61P37/08;A61P43/00 |
主分类号 |
C08B31/18 |
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