发明名称 |
CONTROLLING TRANSGENE EXPRESSION ACROSS THE SKIN |
摘要 |
<p>The invention relates to the use of a skin permeating compound such as phloretin for controlling transgene expression under control of the Pseudomonas putida DOT-T1E- derived bacterial repressor TtgR, to a vector comprising the genetic code for the repressor TtgR fused to a transactivation or a transrepressor domain, to a vector comprising a TtgR- specific operator sequence (OTtgR), a promoter and a polynucleotide coding for an endogenous or exogenous protein, and to a mammalian cell transiently or constitutively transfected with the mentioned vectors, and to mammals comprising such cells in nano- or microcontainers.</p> |
申请公布号 |
WO2010115583(A1) |
申请公布日期 |
2010.10.14 |
申请号 |
WO2010EP02103 |
申请日期 |
2010.04.01 |
申请人 |
ETH ZURICH;FUSSENEGGER, MARTIN;GITZINGER, MARC |
发明人 |
FUSSENEGGER, MARTIN;GITZINGER, MARC |
分类号 |
C12N15/09 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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