发明名称 |
PROCESS FOR PRODUCING RAPIDLY DISINTEGRATING SPHEROIDS (PELLETS), GRANULES AND/OR MIXTURES THEREOF |
摘要 |
<p>Process for producing rapidly disintegrating spheroids (pellets), granules and/or mixtures thereof, which disintegrate in less than 15 minutes. The spheroids comprise at least one active pharmaceutical ingredient, a spheronizing aid material and a solid Polyethylene glycol (PEG) with mean molecular weight (MW) of over 1,000. The process comprises a direct pelletization step in a fluidized bed rotogranulator, using aqueous binding media whilst the temperature of the process does not exceed the melting point of the solid PEG.</p> |
申请公布号 |
WO2010115475(A1) |
申请公布日期 |
2010.10.14 |
申请号 |
WO2009EP56618 |
申请日期 |
2009.05.29 |
申请人 |
SPECIFAR S.A.;POLITIS, STAVROS;CHALKIAS, GEORGIOS |
发明人 |
POLITIS, STAVROS;CHALKIAS, GEORGIOS |
分类号 |
A61K9/16;A61K31/18;A61K31/4439;A61K31/64 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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