摘要 |
The invention provides a process for the preparation of compounds of formula (I), wherein wherein R1 is C1-6-alkyl or C3-6-cycloalkyl, R2 is selected from the group consisting of hydrogen, C1-6-alkyl and C3-6-cycloalkyl, and Q1 is selected from the group consisting of halogen, cyano and -CO-R3, wherein R3 is selected from hydrogen, hydroxy, C1-6-alkoxy, C3-8-cycloalkyloxy, aryloxy, C1-6-alkylamino, aryl-(C1-6-alkyl)amino and di-C1-6-alkylamino, comprising the step of reacting a corresponding o-nitroaniline with an aldehyde R2-CHO or an equivalent thereof in the presence of a reducing agent. |
申请人 |
LONZA LTD;BUECHNER, THOMAS;DRESSEL, MARTINA;HANSELMANN, PAUL;KAISER, RAFAEL;KLEGRAF, ELLEN;ZARAGOZA DOERWALD, FLORENCIO;DING, ZUNLIANG;WONG, HEILAM |
发明人 |
BUECHNER, THOMAS;DRESSEL, MARTINA;HANSELMANN, PAUL;KAISER, RAFAEL;KLEGRAF, ELLEN;ZARAGOZA DOERWALD, FLORENCIO;DING, ZUNLIANG;WONG, HEILAM |