发明名称 |
ANTIMYCOTIC PHARMACEUTICAL COMPOSITION |
摘要 |
In a pharmaceutical composition for external use containing a compound such as luliconazole and/or a salt thereof, comprised are a higher alcohol which is in a liquid state at 1 atm and 25°C. and/or a diester of a dibasic acid, provided that a diester carbonate is excluded, and a polyoxyethylene alkyl ether and/or a polyoxyethylene alkenyl ether. Provided is a preparation using a solvent other than crotamiton, propylene carbonate, and N-methyl-2-pyrroridone as a solvent for solubilization and steric stabilization and having the following properties: 1) when a compound represented by the general formula (1) and/or a salt thereof has a steroisomer, the amount of the stereoisomer of the compound and/or a salt thereof produced under a preservation condition of 60 degrees C. for 3 weeks is 1% by mass or less with respect to the total mass of the compound and/or a salt thereof at the beginning of preservation; 2) the preparation is in a clear liquid state when preserved at a constant temperature of 20°C. immediately after manufacture; and 3) no crystal is deposited when the preparation is preserved at 5°C. for 2 weeks after manufacture. |
申请公布号 |
WO2010117091(A2) |
申请公布日期 |
2010.10.14 |
申请号 |
WO2010JP56884 |
申请日期 |
2010.04.09 |
申请人 |
POLA PHARMA INC.;NIHON NOHYAKU CO., LTD.;KOBAYASHI, HIROKAZU;KOSUGI, EIKO;KUBOTA, NOBUO |
发明人 |
KOBAYASHI, HIROKAZU;KOSUGI, EIKO;KUBOTA, NOBUO |
分类号 |
A61K9/08 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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