发明名称 |
NEURON GENERATION, REGENERATION AND PROTECTION |
摘要 |
The invention demonstrates that, contrary to apoptotic rabies virus G proteins, certain non-apoptotic rabies virus G proteins, such as the G protein of the CVS-NIV strain, have a neurite outgrowth promoting effect. The invention further demonstrates that this neurite outgrowth promoting effect is due to the cytoplasmic tail of said non-apoptotic rabies virus G proteins, more particularly to their PDZ-BS, which shows a single-point mutation compared to the one of apoptotic rabies virus G proteins. The invention provides means for inducing and/or stimulating neurite outgrowth, which are useful in inducing neuron differentiation, for example for the treatment of a neoplasm of the nervous system, as well as in regenerating impaired neurons, for example for the treatment of a neurodegenerative disease, disorder or condition or in the treatment of a microbial infection, or in protecting neurons from neurotoxic agents or oxidative stress. |
申请公布号 |
WO2010116258(A1) |
申请公布日期 |
2010.10.14 |
申请号 |
WO2010IB00967 |
申请日期 |
2010.04.02 |
申请人 |
INSTITUT PASTEUR;THOMAS JEFFERSON UNIVERSITY;PREHAUD, CHRISTOPHE;LAFON, MONIQUE;SCHNELL, MATTHIAS, JOHANNES |
发明人 |
PREHAUD, CHRISTOPHE;LAFON, MONIQUE;SCHNELL, MATTHIAS, JOHANNES |
分类号 |
C12N15/47;A61K38/17;A61K48/00;C07K14/145;C12N15/86 |
主分类号 |
C12N15/47 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|