发明名称 |
EXTENDED-RELEASE PHARMACEUTICAL FORMULATIONS |
摘要 |
The present invention provides matrix-forming, sustained-release pharmaceutical formulations comprising four primary components: i) an effective amount of at least one drug substance; ii) at least one pharmaceutically acceptable, water-swellable, pH independent polymer; iii) at least one pharmaceutically-acceptable, anionic, pH dependent polymer; and (iv) a pharmaceutically-acceptable polymer selected from the group consisting of a) at least one pharmaceutically-acceptable cationic polymer; and b) at least one pharmaceutically acceptable hydrocolloid. The present formulations can be used with compounds having a wide range of solubilities as well as compounds characterized as having hydrophobic or hydrophilic characteristics. |
申请公布号 |
WO2010080580(A3) |
申请公布日期 |
2010.10.14 |
申请号 |
WO2009US68660 |
申请日期 |
2009.12.18 |
申请人 |
AAIPHARMA SERVCIES CORP.;CARDINAL, JOHN R.;JAMES, JACK LAWRENCE;MELSOPP, ELSIE;OAKLEY, DAVID M. |
发明人 |
CARDINAL, JOHN R.;JAMES, JACK LAWRENCE;MELSOPP, ELSIE;OAKLEY, DAVID M. |
分类号 |
A61K9/22;A61K9/26;A61K9/32;A61K9/48;A61K9/54;A61K9/58;A61K31/37;A61K47/30 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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