| 摘要 |
A time and cost effective production method for medical devices with a hydrophilic coating is provided, which ensures adequate adhesion to the substrate, as well as good water retention and low friction properties. Specifically, the method comprises the steps of: providing a substrate;applying, in one or more steps, a coating solution comprising a hydrophilic polymer to a surface of said substrate to form a non-cross linked hydrophilic coating on said substrate; and irradiating the coated substrate, wherein said irradiation is adapted both to cross-link said hydrophilic coating and to simultaneously sterilize the medical device. Hereby, a non-cross linked hydrophilic coating is first obtained on the substrate, which coating is loosely connected to the substrate, and which is not fit for use as a catheter coating. However, after the step of irradiating the coated substrate, the hydrophilic coating becomes cross-linked, and fit for use e.g. on a urinary catheter. Further, since one and the same irradiation step is used to effect both cross-linking and sterilization, the production can be made more efficient, using fewer production steps and with a shortened production time. |
