发明名称 ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS
摘要 Formula I or a pharmaceutically suitable salt thereof, wherein, R1 and R2 independently are hydrogen, deuterium, aryl, hetero aryl, C1-C8 alkyl, optionally being substituted with one or more substituents independently being R3, R3 is an aryl, hetero aryl, fluorine(s), a C1-C6 alkyl containing one or more fluorine, a C1-C6 alkyl containing one or more deuterium, a C1-C6 alkyl containing hydroxy, the aryl and heteroaryl optionally being substituted with one or more halogen, a fluorinated alkoxy, a fluorinated alkyl, a sulfonyl, one or more deuterium, a C1-6 alkyl, a C1-6 alkoxy, a nitrile, or R3 is a C1-6 alkyl optionally substituted with one or more of the following groups: COOR4, OCOR4, CONR5R6, NR5COR6, OR4; wherein, R4 is a C1-10 alkyl optionally substituted with one or more fluorine, deuterium, alkoxy, arylcarboxylate, alkyl carboxylate; R5 and R6 are independently selected from hydrogen, alkyl or they may together form a 4-8 membered carbon ring; or R1 and R2 form a 3-10 membered carbon ring optionally comprising O or N and optionally substituted with a C1-10 alkyl or aryl, hetero aryl optionally substituted with R3.
申请公布号 CA2757879(A1) 申请公布日期 2010.10.14
申请号 CA20102757879 申请日期 2010.04.06
申请人 ASTRAZENECA AB 发明人 BOSTROEM, JONAS;CHENG, LEIFENG;FEX, TOMAS;KARLE, MICHAEL;PETTERSEN, DANIEL;SCHELL, PETER
分类号 C07D413/04;A61K31/4523;A61P7/04 主分类号 C07D413/04
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