MOLECULAR-BASED METHOD OF CANCER DIAGNOSIS AND PROGNOSIS

摘要

A gene profiling signature for diagnosis and prognosis of cancer patients is disclosed herein. In one embodiment, the gene signature includes 32 or 79 cancer survival factor-associated genes. Thus, provided herein is a method of determining the prognosis of a subject with a tumor by detecting expression of five of more cancer survival factor-associated genes in a tumor sample and comparing expression of the five or more cancer survival factor-associated genes in the tumor sample to a control. In some examples, an increase in expression of ABCFl, COROlC, DPP3, PREB, UBE3A, and PTDSSl in a tumor sample compared to a control sample indicates poor prognosis. Also provided is a method of treating a patient diagnosed with cancer by administering a therapeutically effective amount of an agent that alters expression or activity of one or more of the disclosed cancer survival factor- associated genes. Further provided are arrays including probes or antibodies specific for a plurality of cancer survival factor- associated genes or proteins.