发明名称 |
LIPOSOMAL FORMULATIONS OF TOCOPHERYL AMIDES |
摘要 |
Formulations of N-chroman dicarboxylic acid derivatives and their bioisosteres in liposomal systems. Lyophilized liposomal dosage forms of N-chromans, are found to be stable, to achieve therapeutically meaningful plasma levels on administration to a mammalian host, and to demonstrate selective pro-apoptotic oncolytic properties in vivo. Advantageously, these formulations overcome the systemic toxicity that characterized their administration by other dosage forms. |
申请公布号 |
WO2010118200(A2) |
申请公布日期 |
2010.10.14 |
申请号 |
WO2010US30342 |
申请日期 |
2010.04.08 |
申请人 |
SALVATORE, BRIAN;TURANEK, JAROSLAV;NEUZIL, JIRI |
发明人 |
SALVATORE, BRIAN;TURANEK, JAROSLAV;NEUZIL, JIRI |
分类号 |
A61K9/127;A61K31/335;A61P35/00 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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地址 |
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