| 摘要 |
A method for producing cross-linked hyaluronic acid has cross-linking one or more polymers at a low temperature from 10 to 30° C. for a reaction time greater than 48 hours under basic condition with a cross-linking agent to form a cross-linked hyaluronic acid, wherein the polymer is selected from the group consisting of hyaluronic acid, hyaluronate, derivatives thereof and a mixture thereof. Whereby, a cross-linking agent content in a product of the method is decreased so the product does not require purification.
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