METHODS AND COMPOSITIONS FOR SPECIFIC MODULATION OF MCL-1
摘要
A series of stapled BCL-2 family peptide helices were identified as able to target the survival protein MCL-I with high affinity and a subset with unprecedented selectivity. Agents and methods for selective pharmacologic neutralization of MCL-I are provided for drug discovery and therapeutic uses, including use in overcoming the apoptotic resistance of cancer and other diseases associated with impaired cell death.
申请公布号
WO2010068684(A3)
申请公布日期
2010.10.14
申请号
WO2009US67363
申请日期
2009.12.09
申请人
DANA FARBER CANCER INSTITUTE, INC.;WALENSKY, LOREN, D.;STEWART, MICHELLE, L.