MICRORNA SIGNATURE TO PREDICT PROGNOSIS IN HEART FAILURE

摘要

Disclosed are methods and kits for determining prognosis of a subject with left ventricular dysfunction that involve determining expression level of one or more micro RNA ("miRNA") species selected from the group consisting of hsa-miR-367, hsa-miR- 10a, hsa-miR-187, hsa-miR-452, hsa-miR-218, hsa-miR-lOb, hsa-miR-214, hsa-miR- 193a, and hsa-miR-565 in a sample from the subject and comparing the expression level to a reference level. Also disclosed are methods and compositions for treating left ventricular dysfunction that include an inhibitor of CMPXl.