IDENTIFICATION OF REGULATORY T CELLS VIA THE GLOBAL GENE REGULATOR SATB1
摘要
<p>The present invention provides a method for the identification of regulatory T cells based on the diminished abundance or even absence of the global gene regulator SATB1 in such regulatory T cells. In particular, the invention relates to a method utilizing ligands that specifically bind to SATB1 for identifying regulatory T cells which are cells showing a reduced binding to said ligand. Such method is suitable for quality determination of a regulatory T cell population. The invention further provides a kit or diagnostic composition for such method.</p>
申请公布号
WO2010115863(A1)
申请公布日期
2010.10.14
申请号
WO2010EP54488
申请日期
2010.04.06
申请人
BECTON, DICKINSON AND COMPANY;RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAET BONN;SCHULTZE, JOACHIM LUDWIG;BEYER, MARC DANIEL;WARNER, NOEL;BALDERAS, ROBERT
发明人
SCHULTZE, JOACHIM LUDWIG;BEYER, MARC DANIEL;WARNER, NOEL;BALDERAS, ROBERT