发明名称 |
Phosphorylation of histone H3 at threonine 11 - a novel epigenetic mark for transcriptional regulation |
摘要 |
The present invention relates to a process for controlling at least one androgen receptor- (AR-) regulated mechanism in mammalian cells under histone-phosphorylating conditions, said process comprising allowing at least one inhibitor with specificity for at least one protein kinase C-related kinase (PRK) to act on said at least one PRK, thereby modulating, preferably down-regulating, the activity of said at least one PRK and optionally blocking said at least one androgen receptor-regulated mechanism in said mammalian cells.
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申请公布号 |
EP2239581(A1) |
申请公布日期 |
2010.10.13 |
申请号 |
EP20100165430 |
申请日期 |
2007.07.16 |
申请人 |
UNIVERSITAETSKLINIKUM FREIBURG |
发明人 |
SCHUELE, ROLAND;METZGER, ERIC |
分类号 |
A61P35/00;G01N33/574;A61K38/00;A61P13/08;C07K14/47;C07K14/72;C07K16/40;C12N9/12;C12N15/113;C12Q1/48;G01N33/68;G01N33/74 |
主分类号 |
A61P35/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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