发明名称 Bicyclic 6-alkylidene-penems asβ-lactamase inhibitors
摘要 The present invention provides a compound of formula I wherein one of A and B is hydrogen and the other an optionally substituted fused bicyclic heteroaryl group as defined herein; X is O; R5 is H, C1-C6 alkyl, C5-C6 cycloalkyl, or CHR3OCOC1-C6 alkyl; and R3 is hydrogen, C1-C6 alkyl, C5-C6 cycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.
申请公布号 US7812014(B2) 申请公布日期 2010.10.12
申请号 US20080195706 申请日期 2008.08.21
申请人 WYETH LLC 发明人 VENKATESAN ARANAPAKAM MUDUMBAI;MANSOUR TAREK SUHAYL;ABE TAKAO;YAMAMURA ITSUKI;TAKASAKI TSUYOSHI;AGARWAL ATUL;DOS SANTOS OSVALDO;SUM FUK-WAH;LIN YANG-I
分类号 C07D499/897;C07D519/06;A61K31/424;A61K31/43;A61K31/431;A61K31/4365;A61K31/437;A61K31/4985;A61K31/5383;A61K31/542;A61P31/04;A61P43/00;C07D499/88;C07D499/881;C07D503/00;C07D513/04;C07D519/00 主分类号 C07D499/897
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