| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention describes a polymer matrix for controlled release of medicinal agents for local transdermal administration, where the said matrix contains copolymers of acrylic or methacrylic acid and their esters, having Tg lower than 0C, where free carboxyl groups form salts stoichiometric amounts of compatible organic bases. Described also is a method of preparing said matrices, which involves treatment of a copolymer having Tg lower than 0C and free carboxyl groups suspended in an organic solvent with an aqueous solution of organic bases in stoichiometric amounts relative the carboxyl groups, and then addition of an active component and any other auxiliary substances. ^ EFFECT: disclosed matrices improve solubility, stability and diffusion of the agent from the matrix. ^ 9 cl, 5 tbl, 3 ex |
