发明名称 |
HOST CELLS AND METHODS OF PRODUCING DISULFIDE BOND CONTAINING PROTEINS. |
摘要 |
The invention provides for genetically modified Bacillus host cells having decreased cytoplasmic reductase activity, such as decreased TrxA activity, and a nucleic acid encoding a heterologous Staphylococcal oxidase. The invention also provides for methods of producing di-sulfide bond containing proteins using the host cells of the invention and methods of improving protein folding using the host cell of the invention. |
申请公布号 |
MX2010010309(A) |
申请公布日期 |
2010.10.08 |
申请号 |
MX20100010309 |
申请日期 |
2009.03.24 |
申请人 |
DANISCO US INC. |
发明人 |
JEAN-YVES FRANCOIS DUBOIS;ROELOF HENDRIK MATTHIJS KOUWEN;JAN MAARTEN VAN DIJL |
分类号 |
C12N15/75;C12N9/02;C12P21/02 |
主分类号 |
C12N15/75 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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