| 摘要 |
<p>The present invention relates to amino-acid derivatives functionalized with lipids. The amino-acid derivatives are functionalized with lipids via amide, urea or urethane bonds. The derivatives preferably have melting points in the range from 40 to 80 °C. The amino-acid derivative comprises protected lysinediisocyanate. The lipids are chosen from fatty alcohols, fatty amines, fatty acids, cholesterol or sterols. The invention also relates to a process for the preparation of amino-acid derivatives functionalized with lipids via amide, urea or urethane bonds by the reaction of a lipid with a protected lysinediisocyanate. The present invention further relates to the use of the amino acid derivatives in drug delivery.</p> |
