GRANULES CONTAINING LACIDIPINE, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME

摘要

The present invention relates to granules containing lacidipine wherein a mixture of lacidipine, surfactant, and polyvinylpyrrolidone is coated on the surfaces of particles of water-soluble saccharides, and to pharmaceutical compositions comprising same. The lacidipine-containing granules according to the present invention exhibit a superior dissolution rate and solubility in an aqueous medium, and thus improve bioavailability. Specifically, solid preparations such as tablets or the like obtained from the lacidipine-containing granules of the present invention exhibit an improved cumulative dissolution rate within 30 minutes, which is two times faster than conventional preparations, leading to quick pharmacological activity and excellent bioavailability.