DOUBLE-STRANDED MOLECULE INHIBITING THE EXPRESSION OF GPC3

摘要

The invention features an isolated double-stranded molecule inhibiting a growth of GPC3 expressing cell. The invention also features a method for treating GPC3-related disease including esophageal cancer, gastric cancer, hepatic cancer, osteosarcoma, soft tissue cancer or endometriosis by administering the double-stranded molecule against a GPC3 gene. Furthermore, the invention features products, including the double-stranded molecules and vectors encoding them, as well as compositions containing the molecules or vectors, useful in the provided methods.