| 发明名称 |
SUBSTITUTED ISOXAZOLES |
| 摘要 |
The present invention is concerned with novel hydroxy-methyl isoxazole derivatives of formula I wherein R1, R2 and R3 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of the present invention have affinity and selectivity for GABA A α5 receptor. Further the present invention is concerned with the manufacture of the active compounds of formula I, pharmaceutical compositions containing them and their use as pharmaceuticals.
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| 申请公布号 |
US2010256127(A1) |
申请公布日期 |
2010.10.07 |
| 申请号 |
US20100748524 |
申请日期 |
2010.03.29 |
| 申请人 |
BUETTELMANN BERND;GABRIEL STEPHEN DEEMS;HANLON STEVEN PAUL;JAKOB-ROETNE ROLAND;LUCAS MATTHEW C;SPURR PAUL;THOMAS ANDREW;WALDMEIER PIUS |
发明人 |
BUETTELMANN BERND;GABRIEL STEPHEN DEEMS;HANLON STEVEN PAUL;JAKOB-ROETNE ROLAND;LUCAS MATTHEW C.;SPURR PAUL;THOMAS ANDREW;WALDMEIER PIUS |
| 分类号 |
A61K31/465;A61K31/5377;A61K31/541;A61P25/28;C07D413/12;C07D413/14;C07D417/14 |
主分类号 |
A61K31/465 |
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