发明名称 |
PEPTIDE-BASED PASSIVE IMMUNIZATION THERAPY FOR TREATMENT OF ATHEROSCLEROSIS |
摘要 |
PROBLEM TO BE SOLVED: To provide a use of an isolated human antibody or its antibody fragment directed towards at least one oxidized fragment of apolipoprotein B in the manufacture of a pharmaceutical composition for therapeutical or prophylactical treatment of atherosclerosis by means of passive immunization. SOLUTION: In the use of an isolated human antibody or its antibody fragment directed towards at least one oxidized fragment of apolipoprotein B in the manufacture of a pharmaceutical composition for therapeutical or prophylactical treatment of atherosclerosis by means of passive immunization, the oxidized fragment is IEIGLEGKGFEPTLEALFGK, and the antibody or its antibody fragment includes a variable heavy chain domain of a specific sequence and a variable light chain domain of a specific sequence. COPYRIGHT: (C)2011,JPO&INPIT
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申请公布号 |
JP2010222378(A) |
申请公布日期 |
2010.10.07 |
申请号 |
JP20100141960 |
申请日期 |
2010.06.22 |
申请人 |
BIOINVENT INTERNATL AB |
发明人 |
NILSSON JAN;CARLSSON ROLAND;BENGTSSON JENNY;STRANDBERG LEIF |
分类号 |
C07K16/18;A61K39/00;A61K39/395;A61P9/10;A61P37/04;C07K14/775;C12N15/09;C12P21/08 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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