A METHOD OF REGULATING PROLIFERATION AND DIFFERENTIATION OF KERATINOCYES
摘要
<p>Provided are methods of regulating keratinocytes proliferation and differentiation by subjecting keratinocytes to an agent capable of modulating activity or expression of IGFBP7, thereby regulating keratinocytes proliferation and differentiation. Also provided are methods of treating pathologies characterized by hyperproliferative keratinocytes by administering IGFBP7 polypeptide or a polynucleotide encoding IGFBP7 polypeptide to a subject.</p>
申请公布号
WO2010113146(A1)
申请公布日期
2010.10.07
申请号
WO2010IL00167
申请日期
2010.02.28
申请人
THE MEDICAL RESEARCH, INFRASTRUCTURE, AND HEALTH SERVICES FUND OF THE TEL AVIV MEDICAL CENTER;RAPPAPORT FAMILY INSTITUTE FOR RESEARCH IN THE MEDICAL SCIENCES;SPRECHER, ELI;NOUSBECK, JANNA
