<p>The present invention provides various methods of using metabolite profiles correlated with periodontal disease or a health oral status for the diagnosis of periodontal disease, identification of responders and, or non-responders to therapeutic agents for periodontal disease, a method to test the efficacy of test compounds to prevent periodontal disease. The present invention also provides for a dentifrice composition containing an effective amount of a metabolite therapeutic agent which brings about a greater change in metabolite levels compared to a control dentifrice composition.</p>
申请公布号
WO2010114537(A1)
申请公布日期
2010.10.07
申请号
WO2009US39184
申请日期
2009.04.01
申请人
COLGATE-PALMOLIVE COMPANY;BARNES, VIRGINIA, M.;TRIVEDI, HARSH, M.;XU, TAO