METHOD FOR PROVIDING INFORMATION ON ANTIDEPRESSANT THERAPEUTIC EFFECT USING SINGLE NUCLEOTIDE POLYMORPHISM

摘要

The present invention relates to a method for providing information for SSRIs antidepressant therapeutic effect by identifying TPH2 gene polymorphism rs4760815, SLC6A4 gene polymorphism 5-HTTLPR, SLC6A4 gene polymorphism rs2066713, GAD1 gene polymorphism rs3828275, and GRIK2 gene polymorphism rs543196. Thus, it is possible to screen antidepressants on the basis of genetic information, to detect exacerbation and recurrence of depressive symptoms in the early stages, to develop personalized medicines effectively, and to establish a personalized therapeutic model for depression which is suitable for Koreans. In addition, the domestic infrastructure of clinical trials is expanded and thus competitiveness in the pharmaceutical market is secured, and the technology for prediction of drugs can be occupied in advance.