ANTIMICROBIAL CYCLIC PEPTIDES

摘要

The present invention relates to antimicrobial cyclic peptides, which display a reduced hemolytic activity and optionally antimicrobial activity in comparison to parent antimicrobial cyclic peptides from which they are derived. In one embodiment the parent cyclic peptide is gramicidin S. There is also provided a method of providing novel derivative antimicrobial cyclic peptides which have been developed from a parent antimicrobial cyclic peptide and which display a reduced haemolytic activity and/or antimicrobial activity compared to the parent molecule from which they are derived.