NOVEL COPOLYMERS FOR CONTROLLED RELEASE DELIVERY SYSTEM

摘要

The present disclosure relates to pH-sensitive copolymers poly(methacrylic acid-co-N-vinylcaprolactam), designated as P(MAA-co-VCL). The disclosure in particular provides the synthesis of a copolymer of poly(methacrylic acid-co-N-vinylcaprolactam) and its application for pH sensitive oral delivery of active ingredients in vitro and in vivo. The invention in particular provides microparticles comprising the copolymers for controlled release of drug delivery. Methods for delivering drug to the lower GI tract, while avoiding exposure to the stomach acids is provided, methods for treating diabetes using controlled release insulin delivery particles are provided.