ANTIGENIC PEPTIDE OF HSV-2 AND METHODS FOR USING SAME
摘要
<p>The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV, The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.</p>
申请公布号
WO2010115172(A2)
申请公布日期
2010.10.07
申请号
WO2010US29880
申请日期
2010.04.03
申请人
UNIVERSITY OF WASHINGTON;FRED HUTCHINSON CANCER RESEARCH CENTER;COREY, LAWRENCE;LAING, KERRY, J.;WALD, ANNA;KOELLE, DAVID, M.
发明人
COREY, LAWRENCE;LAING, KERRY, J.;WALD, ANNA;KOELLE, DAVID, M.