Proteingemisch enthaltend VSV-G zur Verstärkung der Immunantwort

摘要

#CMT# #/CMT# Use of a cleaned protein mixture comprising at least one part of G-proteins of the vesicular stomatitis virus (VSV-G) and a membrane-constant antigen, which are derived from cytoplasmic replication viruses, for the production of a vaccine to induction or increase of the immune reaction against the membrane-constant antigen. #CMT# : #/CMT# An independent claim is included for a vaccine containing the protein mixture. #CMT#ACTIVITY : #/CMT# Cytostatic. #CMT#MECHANISM OF ACTION : #/CMT# None given. #CMT#USE : #/CMT# The protein mixture is useful for the production of a vaccine for inducing or increasing the immune reaction against the membrane-constant antigen. The protein mixture is useful for production of medicaments to reduce tumor growth (all claimed). No biological data given. #CMT#BIOLOGY : #/CMT# Preferred Components: The replication viruses are plus stranded RNA viruses, minus stranded RNA viruses and double stranded RNA viruses. The replication viruses are coated viruses. The antigen is a F-protein and/or G-protein of respiratory syncytial virus. The VSV-G and the antigen are contained in a diaphragm vesicle. In addition, the VSV-G is diaphragm-constant. The VSV-G and the antigen are in an experimented proprietor cell, preferably in ratio of 50:1-1:50. The VSV-G at least 20 successive amino acids comprising fully defined 71 amino acid (SEQ ID NO: 1) sequence are given in the specification. #CMT#ORGANIC CHEMISTRY : #/CMT# Preferred Components: The vaccine comprises auxiliary and/or auxiliary materials.