| 发明名称 |
TRANSGENIC NON-HUMAN ANIMALS EXPRESSING HUMAN BLOOD CLOTTING FACTORS |
| 摘要 |
The present invention relates, in general, to development of non-human transgenic animals expressing a human blood clotting factor, such as Factor VIII, Factor VII, Factor IX and von Willebrand factor. The invention further provides methods of detecting immunogenic events against human blood clotting factor using the transgenic animals described. |
| 申请公布号 |
EP2235188(A2) |
申请公布日期 |
2010.10.06 |
| 申请号 |
EP20080870385 |
申请日期 |
2008.12.30 |
| 申请人 |
BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE S.A. |
发明人 |
SASGARY, MARIA;SCHUSTER, MARIA;SCHWARZ, HANS-PETER;REIPERT, BIRGIT;ANTOINE, GERHARD;EHRLICH, HARTMUT |
| 分类号 |
C12N15/85;A01K67/027;A61K49/00;C07K14/745;C07K14/755;C12N9/64;G01N33/50 |
主分类号 |
C12N15/85 |
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