摘要 |
<p>The present invention concerns St3Gal6, a new target involved in adipogenesis modulation. Using a siRNA approach, the inventors demonstrated that decrease in St3Gal6 activity in adipose tissue induces a decrease in adipogenesis. Thus, the present invention relates to modulators of St3Gal6 activity as well as screening test for identification of modulators of the activity of this target, and their use, especially in pharmaceutical composition, to modulate adipogenesis and thus treat obesity and related disorders.</p> |