发明名称 |
Reactive Heterocycle-Substituted 7-Hydroxycoumarins and Their Conjugates |
摘要 |
<p>Chemically-reactive, water-soluble, heterocycle-substituted 7-hydroxycoumarin dyes, their bioconjugates and uses are described. The conjugates derived from reactive heterocycle-substituted 7-hydroxycoumarin dyes are used for analyzing biological compounds. These heterocycle-substituted 7-hydroxycoumarin dyes are particularly useful as fluorescent labels for biopolymer detection reagents, such as antibodies or nucleic acid probes. The dye-antibody conjugates of the invention are particularly useful for analyzing analytes using a flow cytometer equipped with a violet laser as an excitation source due to their strong absorption at 405 nm and high fluorescence quantum yield.</p> |
申请公布号 |
EP2236508(A1) |
申请公布日期 |
2010.10.06 |
申请号 |
EP20100158457 |
申请日期 |
2010.03.30 |
申请人 |
BECTON, DICKINSON AND COMPANY |
发明人 |
DIWU, ZHENJUN;DUBROVSKY, TIMOTHY;ABRAMS, BARNABY;LIAO, JINFANG;MENG, QINGLIN |
分类号 |
C07D405/04;A61K49/00;C07D405/14;C07D409/04;C07D409/14;C07D417/04;C07D417/14 |
主分类号 |
C07D405/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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