| 发明名称 |
SIRT1 MODULATORS FOR MANIPULATING CELL/ORGANISM LIFESPAN/STRESS RESPONSE |
| 摘要 |
Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine. |
| 申请公布号 |
EP2236131(A2) |
申请公布日期 |
2010.10.06 |
| 申请号 |
EP20100167645 |
申请日期 |
2004.07.01 |
| 申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;BIOMOL INTERNATIONAL L.P. |
发明人 |
SINCLAIR, DAVID A;HOWITZ, KONRAD T;ZIPKIN, ROBERT E;BITTERMAN, KEVIN J. |
| 分类号 |
A61K31/175;A61K31/00;A61K36/87;A61K45/06;A61P9/00;A61P9/12;A61P19/02;A61P25/28;A61P35/00;A61P43/00;C12N9/16 |
主分类号 |
A61K31/175 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
