| 摘要 |
The invention is directed to a matrix material for MALDI mass spectrometry, to a matrix composition for MALDI mass spectrometry, in particular for aerosol MALDI mass spectrometry, to a MALDI mass spectrometry method, in particular an aerosol MALDI mass spectrometry method, to the use of a specific compound as a MALDI matrix material, and to the use of a MALDI matrix composition in a gas phase coating method. The matrix material of the invention comprises a 2-mercapto-4,5-dialkylthiazole according to formula (I)
wherein X is chosen from S, O or N, and wherein R 1 and R 2 are independently chosen from hydrogen, methyl, methoxy, ethoxy, and propoxy, or wherein R 1 and R 2 are taken together to form an optionally substituted aromatic ring structure, optionally comprising one or more heteroatoms,
or a tautomeric form thereof. A matrix composition includes the matrix material and an alcohol. The alcohol can be halogenated. The MALDI MS method comprises contacting the analyte with the matrix material or the matrix composition; ionising at least part of the analyte, and separating the ionised components using a mass spectrometer, e.g. TOF-MS. Preferably, bioaerosols are contacted with the matrix material in the gas phase. |
