发明名称 |
ATROPISOMERS OF 2-PURINYL-3-TOLYL-QUINAZOLINONE DERIVATIVES AND METHODS OF USE |
摘要 |
The invention provides compounds, compositions and methods to treat certain inflammatory conditions and/or oncology by administering a compound that inhibits PI3K isoforms, particularly the delta isoform. It further provides specific stereoisomers of a compound useful for these methods. In particular, the compound is an optically active atropisomer of 2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one.
|
申请公布号 |
US2010249155(A1) |
申请公布日期 |
2010.09.30 |
申请号 |
US20100731089 |
申请日期 |
2010.03.24 |
申请人 |
EVARTS JERRY B;ULRICH ROGER G |
发明人 |
EVARTS JERRY B.;ULRICH ROGER G. |
分类号 |
A61K31/52;A61P3/10;A61P11/06;A61P17/02;A61P35/00;A61P37/08;C07D473/00 |
主分类号 |
A61K31/52 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|